Do you prefer Prograf or Neoral ?

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Permalink Reply by Robert on June 20, 2009 at 2:52pm

Avoid Prograf, it can slowly cause kidney failure. The effects are often very slow, subtle and can sneak up on you over a long period and this often confounds the specialists who are not aware that Prograf is the culprit in the slow decline of kidney function. Suggest switching to the Cellcept/Rapamune combo protocol.

I have more than five years experience with Prograf and gradual kidney failure leading up to kidney transplant (took over five years for kidneys to fail while taking Prograf). Note that the kidney function was reduced to begin with, so the decline could take longer for patients who begin Prograf with fully functioning kidneys...see above for additional posts.

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Permalink Reply by Robert on June 20, 2009 at 3:48pm

The CEO of Astellas Pharma US, Inc., makers of Prograf were sent a WARNING LETTER (NDA #50-708 and 50-709 Prograf (tacrolimus capsules and injection).

You can read in an FDA warning letter about the specific Nephrotoxicity effects of Prograf:

"...neurotoxicity and nephrotoxicity, particularly when used in high doses. Nephrotoxicity was reported in approximately 52% of kidney transplantation patients and in 40% and 36% of liver transplantation patients receiving Prograf in the U.S. and European randomized trials, respectively (see ADVERSE REACTIONS). . . ."

Here's the Link to one of the FDA Warning Letters:

http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInfo...

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